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  1. Literally making a misstep, figuratively doing something wrong.
  2. Responding to the effects of narcotics.
  3. Freak for any reason. "Don't start tripping, or we'll go toe to toe" -- ??
  4. Acting irrationally

-A synonym used in Chicago is known as tweakin which means mistaken or going crazy. That ain't the right way, you tweakin.